Located on the Sant Pau Health Campus, IR Sant Pau’s mission is to improve people's health and quality of life through the production and dissemination of scientific knowledge, innovation in the field of health, and the application of these advances to clinical practice and health policies.

It is one of the most active research centers in Catalonia, particularly in translational research and the application of discoveries to clinical practice.

The creation of IR Sant Pau marked a qualitative leap in strengthening biomedical and translational research, helping to close the gap between basic research and clinical practice.

Its research areas are aligned with advanced therapies and precision medicine, as well as genomic medicine and rare diseases. It also addresses infectious diseases, diagnostic techniques, and biomarkers, as well as improvements in healthcare.

The institution’s commitment to promoting gender-sensitive research is noteworthy, with the creation of a specific cross-cutting program on women's health and gender

The 9 institutions that form part of the Sant Pau Research Institute are:

• Management Foundation of the Santa Creu i Sant Pau Hospital
• Research Institute Foundation of the Santa Creu i Sant Pau Hospital
• Private Foundation of Santa Creu i Sant Pau Hospital
• Autonomous University of Barcelona.
• Puigvert Foundation.
• Blood and Tissue Bank.
• Ibero-American Cochrane Centre.
• Primary Care Team Sardenya, SLP.
• Public Health Agency of Barcelona.

These are natural allies that, due to proximity and history, have jointly conducted research or collaborated in other scientific areas. Their integration into the IR Sant Pau represents a significant qualitative leap to promote translational research, bridging the gap between basic and clinical research.

The research building, inaugurated on November 15, 2018, was built within the Sant Pau Health Campus, fostering continuous interaction among researchers, both basic and clinical. It spans 9,681 m2 across five floors with modern facilities dedicated to research. Conceived and designed with high environmental and functional criteria, it is primarily constructed with prefabricated, modular, and easily recyclable materials.

In June 2020, the Sant Pau Research Institute building achieved LEED GOLD certification from the U.S. Green Building Council, identifying the building as an example of energy efficiency and sustainability, both in its construction and throughout its lifespan. This certification demonstrates the institution's leadership in energy rationality and the transition toward more sustainable construction.